"HOAt" redirects here. For other uses, see HOAt (disambiguation).

1-Hydroxy-7-azabenzotriazole (HOAt) is a triazole used as a peptide coupling reagent.[2] It suppresses racemization that can otherwise occur during the reaction.[3]

HOAt has a melting point of 213-216 °C.[4]

References

  1. ^ GHS: Sigma Aldrich 445452
  2. ^ Carpino, Louis A (1993). "1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive". Journal of the American Chemical Society. 115 (10): 4397–4398. doi:10.1021/ja00063a082.
  3. ^ Valeur, Eric; Bradley, Mark (2009). "Amide bond formation: beyond the myth of coupling reagents". Chemical Society Reviews. 38 (2): 606–631. doi:10.1039/b701677h. PMID 19169468.
  4. ^ "HOAt". Chemical Book. Retrieved January 30, 2019.
Allikas: http://en.wikipedia.org/wiki/1-Hydroxy-7-azabenzotriazole
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