In enzymology, a (iso)eugenol O-methyltransferase (EC 2.1.1.146) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + isoeugenol S-adenosyl-L-homocysteine + isomethyleugenol

Thus, the two substrates of this enzyme are S-adenosyl methionine and isoeugenol, whereas its two products are S-adenosylhomocysteine and isomethyleugenol.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:isoeugenol O-methyltransferase.

• Wang J, Pichersky E (1998). "Characterization of S-adenosyl-L-methionine:(iso)eugenol O-methyltransferase involved in floral scent production in Clarkia breweri". Arch. Biochem. Biophys. 349 (1): 153–60. doi:10.1006/abbi.1997.0452. PMID 9439593.
• JP, Pichersky E; Lavid, N; Zubieta, C; Chen, F; Beuerle, T; Lewinsohn, E; Noel, JP; Pichersky, E (2002). "Characterization of phenylpropene O-methyltransferases from sweet basil: facile change of substrate specificity and convergent evolution within a plant O-methyltransferase family". Plant Cell. 14 (2): 505–19. doi:10.1105/tpc.010327. PMC 152928. PMID 11884690.