(2R)-3-sulfolactate dehydrogenase (NADP+) (EC 1.1.1.338, (R)-sulfolactate:NADP+ oxidoreductase, L-sulfolactate dehydrogenase, (R)-sulfolactate dehydrogenase, ComC) is an enzyme with systematic name (2R)-3-sulfolactate:NADP+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

(2R)-3-sulfolactate + NADP+ 3-sulfopyruvate + NADPH + H+

The enzyme from the bacterium Chromohalobacter salexigens can only utilize NADP+.

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