Wittes is a surname. It is the surname of:

• Benjamin Wittes (born 1969), American journalist, married to Tamara
• Janet Wittes, American statistician, married to Robert
• Pam and Jon Wittes, American bridge players, 1986 winners of the World Mixed Pairs Championship
• Robert E. Wittes, American physician, married to Janet
• Tamara Cofman Wittes, American foreign policy expert, married to Benjamin