BRCA1-A complex subunit RAP80 is a protein that in humans is encoded by the UIMC1 gene.[5][6]

Repair of DNA damage

RAP80, the protein product of the UIMC1 gene, is a core component of the deubiquitin complex BRCA1-A.[7] Other core components of the BRCA1-A complex are the BRCC36 protein (BRCC3 gene), BRE protein (BRE (gene)), and MERIT40 protein (BABAM1 gene).[7]

BRCA1, as distinct from BRCA1-A, is employed in the repair of chromosomal damage with an important role in the error-free homologous recombinational (HR) repair of DNA double-strand breaks. Sequestration of BRCA1 away from the DNA damage site suppresses homologous recombination and redirects the cell in the direction of repair by the process of non-homologous end joining (NHEJ).[7] The role of BRCA1-A complex appears to be to bind BRCA1 with high affinity and withdraw it away from the site of DNA damage to the periphery where it remains sequestered, thus promoting NHEJ in preference to HR.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000087206Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025878Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yan Z, Kim YS, Jetten AM (Aug 2002). "RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor". J Biol Chem. 277 (35): 32379–88. doi:10.1074/jbc.M203475200. PMID 12080054.
  6. ^ "Entrez Gene: UIMC1 ubiquitin interaction motif containing 1".
  7. ^ a b c Rabl J (October 2020). "BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling". Biomolecules. 10 (11). doi:10.3390/biom10111503. PMC 7692841. PMID 33142801.

Further reading


No tags for this post.