Tkach is a Slavic surname meaning "weaver". It is a common surname in Ukraine, as well as in Russia, Belarus, Poland, Slovakia, Czech Republic and Serbia. Notable people with the surname include:

• Anna Tkach (born 1975), Russian-born Israeli sprinter
• Elena Tkach (born 1970), Russian sport shooter
• Joseph W. Tkach (1927–1995), American religious figure
• Joseph Tkach, Jr. (born 1951), American religious figure, son of Joseph W. Tkach
• Kristina Tkach (born 1999), Russian pool player
• Lyubov Tkach (born 1993), Russian athlete
• Mikhail Tkach (1895–unknown), Ukrainian-born American spy
• Roman Tkach (born 1962), Ukrainian politician
• Serhiy Tkach (1952–2018), Russian-born Ukrainian serial killer
• Svetlana Tkach (born 1969), Moldovan runner
• Walter R. Tkach (1917–1989), American physician
• Yaroslav Tkach (born 2001), Ukrainian speed climber
• Yuliya Tkach (born 1989), Ukrainian Olympic wrestler
• Yuriy Tkach (born 1983), Ukrainian comedian
• Zlata Tkach (1928–2006), Moldovan composer

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