Thomas Burke or Tom Burke may refer to:

• Thomas Burke (artist) (1749–1815), Irish engraver and painter known for mezzotint
• Thomas Burke (author) (1886–1945), English poet and author
• Thomas Burke (tenor) (1890–1969), British operatic tenor
• Tom Burke (actor) (born 1981), English actor

• Thomas Burke (bishop) (circa 1709–1776), Irish Roman Catholic clergyman
• Thomas Nicholas Burke (1830–1882), Irish Roman Catholic theologian and preacher
• Thomas Martin Aloysius Burke (1840–1915), Irish-born Roman Catholic clergyman
• Tom Burke (priest) (1923–2008), Irish Carmelite priest, physicist and schoolteacher

• Thomas Burke (Clare politician) (1876–1951), Irish legislator
• Thomas Burke (North Carolina politician) (c. 1747–1783), Irish-born physician, lawyer and politician
• Sir Thomas Burke, 3rd Baronet (1813–1875), Irish legislator
• Thomas A. Burke (1898–1971), American Democratic city executive and legislator
• Thomas Henry Burke (civil servant) (1829–1882), Irish Catholic Permanent Under Secretary in Britain's Irish Office
• Thomas Henry Burke (politician) (1904–1959), American politician
• Tom Burke (Australian politician) (1910–1973), Labor Party legislator for the Division of Perth
• Sir Thomas Kerry Burke (born 1942), New Zealand Labour Party Member of Parliament
• T. J. Burke (Thomas James Burke, born 1972), American-born Canadian legislator

• Tom Burke (footballer, born 1862) (1862–1914), Welsh footballer
• Tom Burke (hurler) (fl. 1865–1887), Irish hurler
• Thomas Burke (sprinter) (1875–1929), American sprinter, first Olympic champion in the 100 m and 400 m races
• Tom Burke (American football) (born 1976), American National Football League player
• Tom Burke (Irish footballer), Ireland footballer

• Thomas Burke (Medal of Honor sailor) (1833–1883), U.S. Navy sailor and peacetime Medal of Honor recipient
• Thomas Burke (Medal of Honor soldier) (1842–1902), Medal of Honor recipient
• Tom Burke (RAF officer), British senior Royal Air Force air vice-marshal

• Thomas Burke (businessman) (1870–1949), Australian businessman and philanthropist
• Thomas Burke (railroad builder) (1849–1925), American jurist and railroad builder
• Thomas E. Burke (1864–1941), Irish-born American labor union leader
• Thomas J. Burke (North Dakota judge) (1896–1966), American jurist; justice of North Dakota Supreme Court
• Thomas Ulick Burke (1826–1867), bank manager and victim of the Break-o-Day murder in gold-rush Victoria
• Tom Burke (environmentalist) (born 1938), British academic and writer on environmental policy issues
• Tom Burke (Irish revolutionary and sportsman) (1894–1967), Irish revolutionary, sportsman and referee
• William Burke (pirate) (died 1699), sometimes known as Thomas Burke, Irish pirate active in the Caribbean, associate of William Kidd

• Thomas Burke, in the video game Mafia III

• Tomás Burke (fl. 1600–02), Irish gentleman and soldier
• Burke (surname)
• Tommy Burks (1940–1998), American Democratic legislator in Tennessee