The Commission may refer to:

• Sicilian Mafia Commission, the governing body of the Mafia in Italy
• The Commission (American Mafia), the governing body of the Mafia in the United States
• European Commission, the executive branch of the European Union

• The Commission (hip hop), an American hip-hop group from the mid 1990s
• The Commission (album), a 1998 album by Lil' Keke
• "The Commission" (song), a 2021 single by Cain
• The Commission, a secretive time-policing organization featured in The Umbrella Academy

• Commission (disambiguation)
• Decommission (disambiguation)