Scio or SCIO may refer to:
Places
- Chios (Genoese: Scio), a Greek island in the Aegean Sea
United States
- Scio, New York, a town
- Scio (CDP), New York, the primary settlement in the town
- Scio, Ohio
- Scio, Oregon
- Scio Township, Michigan
- Scio, Michigan, an unincorporated community
Other uses
- Science Olympiad, an American elementary, middle, and high school team competition that focuses on various science topics and engineering ability
- Scottish charitable incorporated organisation, a type of charity in Scotland
- State Council Information Office, external name of the Central Propaganda Department of the Chinese Communist Party
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