Orient Express was the name of a long-distance passenger train service that ran from 1883 to 2009.

Orient Express may also refer to:

• American Orient Express, former luxury passenger train set operating in North America 1989–2008
• Venice-Simplon Orient Express, a luxury passenger train service operating in Europe since 1982
• Orient Express (Accor), a luxury passenger train service which will start operating in Europe in 2025
• MS Orient Express, former name of a cruiseferry operating in the Mediterranean 1986–1990
• Eastern and Oriental Express, a luxury passenger train service operating in Southeast Asia since 1993
• Orient Express, an automobile made by "Bergmann Industriewerken" at Gaggenau Baden in the end of the 19th century
• Orient Express, President Ronald Reagan's nickname for the Rockwell X-30 spaceplane.

• Orient Express (1927 film), 1927 German silent thriller film
• Orient Express (1934 film), the film version of the novel Stamboul Train
• Orient Express (1943 film), 1943 Hungarian film
• Orient Express (1944 film), 1944 German crime film
• Orient Express (1954 film), 1954 Italian film starring Eva Bartok
• Orient Express (2004 film), Romanian film

• Orient Express, nickname for poker player Johnny Chan
• "Orient Express", a single by Jean-Michel Jarre from Les Concerts en Chine
• "Orient Express", a 1967 single by the Lee Kings
• Orient Express (board game), a board game set on the train
• Orient Express (magazine), an Italian comics magazine
• Orient Express (roller coaster), a former roller coaster at Worlds of Fun in Kansas City, United States
• Orient Express (TV series), a 1953 anthology drama television series
• Orient Express Racing Team, French yacht racing team
• Orient-Express Hotels, former name of the UK-based leisure company Belmond Ltd.
• Stamboul Train, 1932 novel by Graham Greene (titled Orient Express in the US)
• The Orient Express, a wrestling tag-team from the early 1990s

• Murder on the Orient Express, 1934 Agatha Christie novel
  • Murder on the Orient Express (disambiguation), various things based on the novel