Nemertelline is a neurotoxic tetra-pyridine compound originally found in the marine ribbon worm Amphiporus angulatus.[1] These worms produce a variety of toxins which are used both in hunting their prey and in defending themselves from predators.[2] Interest in potential application of this compound as an antifouling agent for boats and other marine installations has led to attempts to produce it synthetically by convenient routes.[3] Its toxicity is similar to nicotine in crustaceans but has no mammalian toxicity. It is similar to nicotelline in structure.[4]

References

  1. ^ Kem WR, Scott KN, Duncan JH (June 1976). "Hoplonemertine worms -- a new source of pyridine neurotoxins". Experientia. 32 (6): 684–6. doi:10.1007/BF01919831. PMID 181266.
  2. ^ Kem WR, Soti F, Rittschof D (July 2003). "Inhibition of barnacle larval settlement and crustacean toxicity of some hoplonemertine pyridyl alkaloids". Biomolecular Engineering. 20 (4–6): 355–61. doi:10.1016/S1389-0344(03)00049-2. PMID 12919820.
  3. ^ Bouillon A, Voisin AS, Robic A, Lancelot JC, Collot V, Rault S (December 2003). "An efficient two-step total synthesis of the quaterpyridine nemertelline". The Journal of Organic Chemistry. 68 (26): 10178–80. doi:10.1021/jo034805b. PMID 14682721.
  4. ^ Kem WR, Scott KN, Duncan JH (June 1976). "Hoplonemertine worms -- a new source of pyridine neurotoxins". Experientia. 32 (6): 684–6. doi:10.1007/BF01919831. PMID 181266.


Allikas: Https://en.wikipedia.org/wiki/Nemertelline
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