The following people were born or based their life in Vellore.

• V. L. Ethiraj, founder, Ethiraj College for Women
• V. M. Muralidharan, chairman, Ethiraj College for Women
• Benjamin Pulimood, director/principal, Christian Medical College & Hospital
• G. Viswanathan, founder and chancellor, VIT University

• Mecca Rafeeque Ahmed, founder and managing director of FARIDA Group

• Radhika Apte, Bollywood actress
• Aryan, Indian film actor
• Bhaskar, director of Bommarilu, Paragu, Orange, Ongole Githa, Bangalore Naatkal
• Vani Jairam, playback singer
• R. Nataraja Mudaliar, known as the father of Tamil cinema, a pioneer in the production of silent films
• Dinesh Ravi, Tamil actor of Attakathi and Visaranai fame
• Nelson Dilipkumar, Director of Kolamaavu Kokila, Doctor, Beast, Jailer.
• Poornima Ravi, Tamil film actress
• Indhuja Ravichandran, Tamil film actress
• V. Ravichandran, Indian film producer and distributor
• Aravinnd Singh, cinematographer of Tamil films Demonte Colony and Diary
• Vellore A. R. Srinivasan, classical carnatic musician
• Thiru, Tamil film director
• Vishnu Vishal, Tamil actor
• N. Viswanathan, Bengali actor

• C. Gnanasekaran, Indian politician and former Member of the Legislative Assembly of Tamil Nadu
• C. Abdul Hakim, Indian politician and businessman
• Durai Murugan, Indian politician and Ex-Minister for Public Works, Govt. of Tamil Nadu
• Abdul Rahman, Indian politician and former member of the Parliament of India from Vellore Constituency
• V. S. Vijay, Indian politician and incumbent member of the Tamil Nadu legislative assembly from Vellore constituency and Ex-Minister for Health, Govt. of Tamil Nadu

• Palani Amarnath, former player of IPL Chennai Superkings and Tamil Nadu Ranji Trophy
• M Tamil Selvan, won silver medal in 1978 & 1982 Commonwealth Games
• Sathish Sivalingam, won gold medal in 77 kg category in 2014 & 2018 Commonwealth Games

• C. Mohan, well known computer scientist in Silicon Valley, an IBM Fellow and the former IBM India Chief Scientist

• Azhagiya Periyavan (pen name of C.Aravindan), journalist and author