HLA may refer to:

• Hacienda Lipangue Airport, Chile
• Huslia Airport (FAA LID: HLA), in Alaska, United States
• Lanseria International Airport (IATA: HLA), near Johannesburg, South Africa

• Hla Myint (Brigadier General) (born 1940s), Burmese politician
• Hla Myint (1920–2017), Burmese economist
• Hla Pe (1913–2007), Burmese linguist
• Hla Thaung (died 1949), Burmese soldier
• M.T. Hla (U Tun Hla) (1874–1946), Burmese painter
• Min Saw Hla (1532–1564), king of Arakan
• Sanda Min Hla (died 1363), Chief queen consort of Hanthawaddy
• Saw Min Hla (fl. 1422–1425), Chief queen consort of Ava

• Heath Lane Academy, in Earl Shilton, Leicestershire, England
• Hidden Lake Academy, in Georgia, United States
• Hillcrest Lutheran Academy, in Minnesota, United States

• High Level Architecture, a distributed computer simulation standard
• High Level Assembly, an Intel 80x86 Assembly Language
• HLA (journal), a scientific journal
• HLA Informatics Group
• Human leukocyte antigen, a locus of genes
• Hydraulic Launch Assist, a proprietary regenerative braking system
• Hydraulic lash adjuster, another name for a hydraulic tappet

• Handball League Australia, an Australian handball league
• Handball Liga Austria, the name of the professional handball league in Austria

• HLA (radio station), a South Korean time signal station
• Half-Life: Alyx, a 2020 video game by Valve
• Halia language, in Papua New Guinea
• Haryana Legislative Assembly, the unicameral state legislature of Haryana state in India
• Hawaii Library Association, professional organization for librarians in Hawaii
• Heilan Home, a Chinese clothing brand
• 2024 Los Angeles Measure HLA, a ballot initiative mandating compliance with the city mobility plan