Giulio Cesare (Italian, 'Julius Caesar'), is an opera by Handel first performed in 1724.

Giulio Cesare may also refer to:

• Giulio Cesare Martinengo (c. 1568 – 1613), Italian composer and teacher
• Giulio Cesare la Galla (1576–1624), Italian professor of philosophy
• Giulio Cesare Vanini, pen name of Lucilio Vanini (1585–1619), Italian philosopher, physician and free-thinker

• Italian battleship Giulio Cesare, 1911–1949
• SS Giulio Cesare, an Italian ocean liner 1923–1944
• MS Giulio Cesare, an Italian ocean liner 1950–1973

• Cesare (disambiguation)
• Julius Caesar (disambiguation)