Esmaili (Persian: اسماعيلی) may refer to:

• Esmaili, Iran, a village in Kerman Province
• Esmaili-ye Olya (disambiguation)
  • Esmaili-ye Olya, Ilam
  • Esmaili Olya, Kerman
• Esmaili-ye Sofla (disambiguation)
  • Esmaili-ye Sofla, Ilam
  • Esmaili Sofla, Kerman
• Esmaili District, in Kerman Province
• Esmaili Rural District, in Kerman Province

• Ali Esmaeili (born 1996), Iranian footballer
• Fariborz Esmaeili (1940–2020), Iranian footballer
• Farshid Esmaeili (born 1994), Iranian footballer
• Lazım Esmaeili (also "Lazem") (1945–1995), Kurdish Iranian spy operating in Turkey
• Mohammad Esmaeili (born 1960), Iranian conservative politician
• Mohsen Esmaeili (born 1964), Iranian consulting jurist and member of both the Guardian Council and Assembly of Experts
• Tareq Esmaeili (born 1977), Qatari cyclist

• Ardalan Esmaili (born 1986), Iranian-born Swedish actor
• Farzad Esmaili (born 1972), Iranian military officer, a commander of the Iranian Air Defense Force
• Habiballah Esmaili, Iranian historian

• Ismaili (disambiguation), variant of Arabic-based Ismaili / Ismaily
• Ismaili (surname), variant of Arabic-based Ismaili / Smaily