Edessa is the historical name of a city in Mesopotamia, now Şanlıurfa, Turkey.

Edessa may also refer to:

• Edessa (bug), a large genus of stink bugs
• Edessa, Greece
• County of Edessa, a crusader state
• Osroene, an ancient kingdom and province of the Roman Empire
• Bishopric of Edessa
• Edessa, birth name of Jarael, a character in Star Wars: Knights of the Old Republic (comics)

• All pages with titles beginning with Edessa
• All pages with titles containing Edessa
• Edosa, a moth genus
• Odessa (disambiguation)
• Odesa (disambiguation)