Duque de Caxias may refer to:
- Luís Alves de Lima e Silva, Duke of Caxias (1803–1880), patron of the Brazilian Army; namesake for the following:
- Duque de Caxias, Rio de Janeiro, a city in the state of Rio de Janeiro in southeastern Brazil
- Duque de Caxias (U-11), a Brazilian Navy transport ship; the former USS Orizaba
- Brazilian landing ship Duque de Caxias (G26)
- Duque de Caxias Futebol Clube, a Brazilian football team
- Esporte Clube Tigres do Brasil of Duque de Caxias
- Duque de Caxias, Santa Maria
- CEPE-Caxias
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