De Clerck is a Dutch surname, particularly common in Flanders. In the province of West Flanders, the name is usually concatenated to Declerck. People with the surname include:

• Albert De Clerck [nl] (1914–1974), Belgian politician and government minister
• Carl Alexander Clerck (1709–1765), Swedish entomologist and arachnologist
• Hendrik de Clerck (c. 1560 – 1630), Flemish painter
• Jacques de Clerck (c. 1582 – 1624), Antwerp-born Dutch merchant, admiral, and explorer
• Jeanne Albertine Colin-De Clerck (born 1924), Belgian composer
• Marc De Clerck (born 1949), Belgian football goalkeeper
• Olivier De Clerck (born 1971), phycologist with the standard author abbreviation "De Clerck"
• Richard Declerck (1899–1986), Belgian lawyer and politician
• Roger De Clerck (1924–2015), Belgian entrepreneur
• Stefaan Maria Joris Yolanda De Clerck (born 1951), Belgian politician