Challis may refer to:

• Challis (surname)

• Challis, Idaho
• Challis, New Zealand

• Challis (crater), a crater on Earth's moon
• Challis railway station
• "Challis", a song by American heavy metal band Dio off their 2000 studio album Magica
• Challis (fabric), a printed woven fabric.

• Chalice, a cup used in ceremonies such as the Eucharist
• Chalise, a surname