Anastrepha grandis is a fruit fly, also known as the South American cucurbit fruit fly. It is a pest of various cultivated species of Cucurbitaceae, especially the pumpkin, squash and melon.^[1] Anastrepha grandis is found in almost all South American countries.

Once a pest of minor to moderate importance generally, it has become a rather important pest.^[2][3] This kind of species is potentially of economic importance in Florida and southern Texas should it ever be introduced there.