Americus may refer to:

• Americus, Georgia, a city with a population of around 17,000
• Americus, Indiana, a small town in Washington Township
• Americus, Kansas, a city with a population of around 900
• Americus, Missouri, an unincorporated community
• Americus Township, Lyon County, Kansas

• Americus (given name)
• Americus Backers (died 1778), described as the father of the English grand pianoforte style
• Americus Mayo (died 1891), American politician, state legislator in Arkansas
• Americus Vespucius Rice (1835–1904), American politician, banker, and businessman
• Amerigo Vespucci (1454–1512) Italian merchant, explorer and cartographer whose first name was Americus in Latin
• Saint Emeric of Hungary (died 1031), also known as Saint Americus or Emeric, a Hungarian prince
• Americus Symmes (1811–1896), son of John Cleves Symmes Jr.

• Americus (baseball team), a minor league club that represented the city of Americus, Georgia
• Americus Hotel, historic building in Allentown, Pennsylvania
• Americus, Preston and Lumpkin Railroad, historic railroad that operated in the states of Georgia and Alabama
• Americus (horse) (died 1910), an American Thoroughbred racehorse
• Americus, a 2011 graphic novel by M. K. Reed, published by First Second Books