Afzal may refer to:

• Afzal, Iran, a village
• Chah Afzal, Yazd, a village

• Afzal Ansari (born 1953), Indian politician
• Afzal Hossain (born 1954), Bangladeshi actor, director, writer and painter
• Afzal Khan (British politician) (born 1958), British Labour Party politician
• Afzal Khan (general) (died 1659), a medieval Indian commander
• Afzal Khan (actor), better known as John Rambo, Pakistani actor and comedian
• Afzal Kahn (automotive designer), British automotive designer
• Afzal Guru or Mohammad Afzal, (1969–2013), a Kashmiri terrorist, who was convicted for his role in the 2001 Indian Parliament attack
• Afzal Ahmed Khan, Indian film director and producer
• Afzal Khokhar (born 1974), Pakistani politician
• Afzal Ahmed Syed, Urdu poet and translator
• Afzal Sharif, Bangladeshi television and film actor
• Afzal Tahir, (born 1949), Pakistani admiral, writer and military historian
• Afzal Yusuf, Indian music composer in the South Indian film industry

• Muhammad Afzal Sindhu (born 1935), Pakistani politician and lawmaker who is a member of the National Assembly
• Nadeem Afzal Chan (born 1975), aka Nadeem Afzal Gondal, Pakistani politician
• Saira Afzal Tarar (born 1966), Pakistani politician and government minister

• Abdullah Afzal (born 1989), English actor and stand-up comedian of Pakistani British descent
• Fawzia Afzal-Khan, university professor
• Nazir Afzal (born 1962), British lawyer who campaigns on issues around child sexual exploitation and violence against women
• Sahiba Afzal, Pakistani film actress
• Syed Muhammad Afzal, Bengali politician
• Tanwir Afzal (born 1988), Hong Kong cricketer

• Articles beginning with "Afzal"
• Afzal Khan (disambiguation), several people
• Chah Afzal (disambiguation), various locations in Iran
• Mohammad Afzal (disambiguation), several people