Saint Afra (died 304) was a Christian martyr.

Afra or AFRA may also refer to:

• Afra, Iran; a village in Mazandaran Province, Iran
• Afra, Morocco; a village near Agdz
• Afra Bay, Andaman and Nicobar Islands, India
• St. Ulrich's and St. Afra's Abbey, Augsburg, Bavaria, Germany
• Sächsisches Landesgymnasium Sankt Afra zu Meißen, a school for gifted students in Meißen, Germany

• Afra Airlines, in Ghana
• Aircraft Fleet Recycling Association (AFRA)
• American Federation of Radio Artists (AFRA), later becoming the American Federation of Television and Radio Artists (AFTRA), later becoming SAG-AFTRA (Screen Actors Guild -- American Federation of Television and Radio Artists)

• Afra (name)
• Afra (moth), a genus of snout moths in the subfamily Epipaschiinae
• Afra language, a nearly extinct Papuan language

• Aframax, a size limitation on ships passing through the Suez Canal
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• Aphra