Maxime Cressy defeated Alexander Bublik in the final, 2–6, 6–3, 7–6^(7–3) to win the men's singles tennis title at the 2022 Hall of Fame Open. It was his maiden ATP Tour title.^[1]

Kevin Anderson was the reigning champion,^[2] but retired from professional tennis in May 2022.^[3]

The top four seeds received a bye into the second round.

	Semifinals							Final
		Jason Kubler	3	2
	3	Alexander Bublik	6	6
								3	Alexander Bublik	6	3	63
								4	Maxime Cressy	2	6	77
	4	Maxime Cressy	6	4	6
	2	John Isner	2	6	3

	First round							Second round							Quarterfinals							Semifinals
								1/WC	F Auger-Aliassime	6	3	64
		J Kubler	6	6					J Kubler	4	6	77
		J Thompson	2	3												J Kubler	7	77
		Q Halys	77	6											8	J Duckworth	5	63
		A Popyrin	65	3					Q Halys	5	6	2
	Q	L Broady	2	6	2			8	J Duckworth	7	3	6
	8	J Duckworth	6	4	6																		J Kubler	3	2
																						3	A Bublik	6	6
								3	A Bublik	6	3	6
		R Albot	1	62					J Sock	3	6	2
		J Sock	6	77											3	A Bublik	7	6
	WC	M Purcell	6	1	7										6/WC	A Murray	5	4
		A Mannarino	3	6	5			WC	M Purcell	6	2	1
		S Querrey	2	0				6/WC	A Murray	4	6	6
	6/WC	A Murray	6	6

	First round							Second round							Quarterfinals							Semifinals
	7	J Veselý	6	6
		F López	4	2				7	J Veselý
		S Kozlov	5	3					S Johnson	w/o
		S Johnson	7	6												S Johnson	77	4	4
	Q	M Krueger	79	4	6										4	M Cressy	63	6	6
		T van Rijthoven	67	6	3			Q	M Krueger	3	4
								4	M Cressy	6	6
																						4	M Cressy	6	4	6
	5	B Bonzi	2	6	6																	2	J Isner	2	6	3
	Q	W Blumberg	6	3	2			5	B Bonzi	6	77
		D Koepfer	4	5				Q	C Eubanks	4	65
	Q	C Eubanks	6	7											5	B Bonzi	62	78	65
		P Gojowczyk	7	6											2	J Isner	77	66	77
		U Humbert	5	4					P Gojowczyk	3	66
								2	J Isner	6	78

	First round							Qualifying competition
	1	Ernesto Escobedo	61	1
	Alt	Noah Rubin	77	6
								Alt	Noah Rubin	6	3	2
								WC	William Blumberg	4	6	6
	WC	William Blumberg	3	7	6
	5	Ramkumar Ramanathan	6	5	4

	First round							Qualifying competition
	2	Liam Broady	6	6
	WC	Evan King	3	2
								2	Liam Broady	6	6
									Brandon Holt	1	3
		Brandon Holt	4	6	7
	7	Gijs Brouwer	6	3	5

	First round							Qualifying competition
	3	Mitchell Krueger	3	6	6
		Evan Zhu	6	4	1
								3	Mitchell Krueger	6	6
									Gage Brymer	1	4
		Gage Brymer	2	6	77
	6	Wu Tung-lin	6	3	63

	First round							Qualifying competition
	4	Christopher Eubanks	6	6
		Peđa Krstin	0	2
								4	Christopher Eubanks	78	7
								8	Mirza Bašić	66	5
		Jason Jung	3	4
	8	Mirza Bašić	6	6

• Main draw
• Qualifying draw