The 2022 Guanajuato Open was a professional tennis tournament played on outdoor hard courts. It was the fourteenth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Irapuato, Mexico between 7 and 13 March 2022.^[1]

Country	Player	Rank1	Seed
CHN	Zhu Lin	119	1
CAN	Rebecca Marino	142	2
	Anastasia Gasanova	155	3
NED	Arianne Hartono	164	4
USA	Robin Anderson	172	5
SWE	Mirjam Björklund	186	6
GRE	Valentini Grammatikopoulou	189	7
USA	Jamie Loeb	194	8

• ¹ Rankings are as of 28 February 2022.

The following players received wildcards into the singles main draw:

• Gala Arangio
• Claudia Sofía Martínez Solís

The following player received entry as a special exempt:

• Adriana Reami

The following players received entry from the qualifying draw:

• Kaitlyn Christian
• Ellie Douglas
• Dalayna Hewitt
• Jessica Hinojosa Gómez
• Zoe Hitt
• Ana Paula Martínez Mora
• María Fernanda Navarro
• Erica Oosterhout

The following players received entry as lucky losers:

• Ana María Becerra
• Sylvia Schenck

• Zhu Lin def. Rebecca Marino, 6–4, 6–1

• Kaitlyn Christian / Lidziya Marozava def. Anastasia Tikhonova / Daniela Vismane, 6–0, 6–2

• 2022 Guanajuato Open at ITFtennis.com
• Official website