Niels Vink defeated Sam Schröder in the final, 6–4, 7–6^(10–8) to win the quad singles wheelchair tennis title at the 2022 French Open. It was his first major singles title.

Dylan Alcott was the three-time reigning champion,^[1] but retired from professional wheelchair tennis in January 2022.^[2]

	Quarterfinals							Semifinals							Final
	1	Niels Vink	6	6
		Andy Lapthorne	0	0
								1	Niels Vink	6	6
									Heath Davidson	3	1
		Koji Sugeno	3	3
		Heath Davidson	6	6
															1	Niels Vink	6	710
															2	Sam Schröder	4	68
	WC	Ymanitu Silva	1	6	4
		David Wagner	6	3	6
									David Wagner	3	3
								2	Sam Schröder	6	6
		Donald Ramphadi	3	5
	2	Sam Schröder	6	7

• Draw^{[permanent dead link‍]}