The 2022 Challenger Banque Nationale de Drummondville was a professional tennis tournament played on indoor hard courts. It was the 15th edition of the tournament and part of the 2022 ATP Challenger Tour. It took place in Drummondville, Canada between November 14 and 20, 2022.

Country	Player	Rank1	Seed
ECU	Emilio Gómez	107	1
USA	Michael Mmoh	115	2
CAN	Vasek Pospisil	118	3
ARG	Juan Pablo Ficovich	140	4
FRA	Enzo Couacaud	183	5
FRA	Antoine Escoffier	216	6
CAN	Alexis Galarneau	222	7
CAN	Gabriel Diallo	248	8

• ¹ Rankings are as of November 7, 2022.^[1]

The following players received wildcards into the singles main draw:

• Taha Baadi
• Justin Boulais
• Marko Stakusic

The following player received entry into the singles main draw using a protected ranking:

• Julian Ocleppo

The following player received entry into the singles main draw as an alternate:

• Malek Jaziri

The following players received entry from the qualifying draw:

• Liam Draxl
• Maks Kaśnikowski
• Joshua Lapadat
• Max Hans Rehberg
• Roy Smith
• Kai Wehnelt

The following player received entry as a lucky loser:

• Constantin Frantzen
• Roko Horvat

• Vasek Pospisil def. Michael Mmoh 7–6^(7–5), 4–6, 6–4.

• Julian Cash / Henry Patten def. Arthur Fery / Giles Hussey 6–3, 6–3.