Dylan Alcott defeated the defending champion David Wagner in the final, 7–5, 6–2 to win the quad singles wheelchair tennis title at the 2018 US Open.

	Final
	2	Dylan Alcott	7	6
	1	David Wagner	5	2

		Wagner	Alcott	Lapthorne	Barten	RR W–L	Set W–L	Game W–L	Standings
1	David Wagner		3–6, 5–7	6–2, 6–4	6–0, 6–1	2–1	4–2 (67%)	32–20 (62%)	2
2	Dylan Alcott	6–3, 7–5		6–0, 3–6, 6–0	6–3, 6–1	3–0	6–1 (86%)	40–18 (69%)	1
	Andrew Lapthorne	2–6, 4–6	0–6, 6–3, 0–6		6–1, 6–4	1–2	3–4 (43%)	24–32 (43%)	3
WC	Bryan Barten	0–6, 1–6	3–6, 1–6	1–6, 4–6		0–3	0–6 (0%)	10–36 (22%)	4

Standings are determined by: 1. number of wins; 2. number of matches; 3. in two-players-ties, head-to-head records; 4. in three-players-ties, percentage of sets won, or of games won; 5. steering-committee decision.

• Draw