Defending champions Andrew Lapthorne and David Wagner defeated Dylan Alcott and Bryan Barten in the final, 3–6, 6–0, [10–4] to win the quad doubles wheelchair tennis title at the 2018 US Open.
Seeds
Andrew Lapthorne / 
David Wagner (champions)
Dylan Alcott / Bryan Barten (final)
Draw
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Bracket
| Final | ||||||
| 1 | Andrew Lapthorne David Wagner
| 3 | 6 | [10] | ||
| 2 | Dylan Alcott Bryan Barten
| 6 | 0 | [4] | ||
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