The 2012–13 season was Sevilla Football Club's 12th consecutive season in La Liga and its first season without participating in European competitions since 2004–05. The team manager in the previous season, Míchel, continued with the team.

In (6 players)
Player	From	Fee
Diego López	Villarreal	€3,500,000
Hedwiges Maduro	Valencia	Free
Bryan Rabello	Colo-Colo	Free
Geoffrey Kondogbia	Lens	€3,000,000
Cicinho	Palmeiras	€2,000,000
Alberto Botía	Sporting Gijón	€3,000,000

Out (7 players)
Player	New Team	Fee
Martín Cáceres	Juventus	€9,500,000
Arouna Koné	Levante	Free
Frédéric Kanouté	Beijing Guoan	Free
Emiliano Armenteros	Osasuna	Free
Julien Escudé	Beşiktaş	Free
Romaric	Zaragoza	Free
Tom de Mul	Free agent

Loan out (6 players)
Player	Team
Javi Varas	Celta Vigo
Alexis	Getafe
Tiberio Guarente	Bologna
Luis Alberto	Barcelona B
Lautaro Acosta	Boca Juniors
Hiroshi Ibusuki	Eupen

Loan return (2 players)
Italics for players returning to the club but left it during pre-season
Player	From
Bernardo	Racing Santander
Javi Hervás	Córdoba
Martín Cáceres	Juventus
Arouna Koné	Levante
Emiliano Armenteros	Rayo Vallecano
Alexis	Getafe
Romaric	Espanyol
Lautaro Acosta	Racing Santander

Promotion from youth system (1 player)
Italics for players who were promoted from youth system but left the team during pre-season
Player	Date of birth (Age)
Álex Rubio	(1993-07-23)23 July 1993 (aged 18)
Hiroshi Ibusuki	(1991-02-27)27 February 1991 (aged 21)

In (1 player)
Player	From	Fee
Miroslav Stevanović	Vojvodina	€1,000,000

Out (1 player)
Player	New Team	Fee
Diego López	Real Madrid	€4,000,000

Loan in (1 player)
Player	From
Beto	Braga

Loan out (2 players)
Player	Team
Bernardo	Sporting Gijón
Antonio Luna	Mallorca

Promotion from youth system (1 player)
Italics for players who were promoted from youth system but left the team during pre-season
Player	Date of birth (Age)
Julián Cuesta	(1991-03-28)28 March 1991 (aged 21)

As of 30 January 2013

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.

No. Pos. Nation Player 1 GK  ESP Andrés Palop (captain) 2 DF  ARG Federico Fazio 3 DF  ESP Fernando Navarro 4 DF  BIH Emir Spahić 5 DF  ESP Cala 6 MF  ESP José Campaña 7 MF  ESP Jesús Navas 8 MF  CHI Gary Medel 9 FW  ESP Álvaro Negredo 10 MF  ARG Diego Perotti 11 MF  CRO Ivan Rakitić 12 DF  NED Hedwiges Maduro 13 GK  POR Beto (On loan from Braga) 14 FW  ESP Manu

No. Pos. Nation Player 15 MF  GER Piotr Trochowski 17 MF  ESP Javi Hervás 18 MF  BIH Miroslav Stevanović 19 MF  ESP José Antonio Reyes 20 FW  SEN Baba Diawara 21 DF  BRA Cicinho 22 MF  FRA Geoffrey Kondogbia 23 DF  ESP Coke 24 DF  ESP Alberto Botía 28 FW  ESP Álex Rubio 29 GK  ESP Julián Cuesta 30 MF  CHI Bryan Rabello

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.

No. Pos. Nation Player 26 DF  ESP Francisco Javier Atienza 27 MF  ESP Jozabed 31 MF  ESP Joaquín García 32 FW  ESP Jonathan Diego Menéndez 33 MF  ESP Antonio Jesús Cotán 34 DF  ESP Israel Puerto 35 DF  ESP Alberto Moreno 36 GK  ESP Néstor Díaz 37 GK  ESP Sergio Rico

No. Pos. Nation Player 38 DF  ESP Samu 39 MF  ENG Alban Bunjaku 40 DF  ESP Martí Tapia 41 FW  ESP Gonzalo – MF  ESP Salva Rivas – DF  ESP Modesto Acosta – DF  ESP Daniel Pérez – MF  ESP Jesús Alfaro

Out between: July 2012 – September 2012

On 28 July, Sevilla announced that Hedwiges Maduro was suffering from a congenital anomaly in his heart. It was detected in a special examination by physicians during the second part of the team's summer concentration in Costa Ballena, near Rota. The club said days after that the player had traveled to Houston, Texas, for an examination and a full diagnosis. Maduro said after the first extensive revisions made in Spain that his life was not in danger. After being investigated in Houston by Dr. Paolo Angelini, Sevilla medical services made public that Maduro's abnormality would not prevent him from playing football professionally, and he could rejoin the squad as normal, in late August.

Out between: September 2012 – May 2013

After scoring the first goal of the match against Barcelona on 29 September, Piotr Trochowski had to leave the match with a knee injury. Sevilla's medical services analyzed his illness during the following days. The treatment he received first failed, and doctors thought it was appropriate to operate him in late October in Denver, Colorado. After the surgery, the club told press that the time without playing would be eight months, figuring that his reappearance could be in May 2013, meaning he would miss the remainder of the season.

List of players called up by their national team
Updated to 22 January 2013
4	Emir Spahić	Bosnia and Herzegovina	v.  Wales (15 August 2012) v.  Liechtenstein (7 September 2012) v.  Latvia (11 September 2012) v.  Greece (12 October 2012) v.  Lithuania (16 October 2012) v.  Algeria (14 November 2012)
7	Jesús Navas	Spain	v.  Puerto Rico (15 August 2012) v.  Saudi Arabia (7 September 2012) v.  Georgia (11 September 2012) v.  Belarus (12 October 2012) v.  France (16 October 2012) v.  Panama (14 November 2012)
8		Croatia	v.   Switzerland (15 August 2012) v.  North Macedonia (7 September 2012) v.  Belgium (11 September 2012) v.  North Macedonia (12 October 2012) v.  Wales (16 October 2012)
16	José Campaña	Spain U19	v.  Greece (3 July 2012) v.  Portugal (6 July 2012) v.  Estonia (9 July 2012) v.  France (12 July 2012) v.  Greece (15 July 2012)
22	Geoffrey Kondogbia	France U20	v.  Ukraine (13 November 2012)
28	Álex Rubio	Spain U20	v.  Japan (17 August 2012) v.  Saudi Arabia (19 August 2012) v.  Argentina (21 August 2012) v.  South Korea (22 August 2012) v.  Argentina (23 August 2012)
30	Bryan Rabello	Chile U20	v. France U21 (10 September 2012) v.  Argentina (10 January 2013) v.  Bolivia (12 January 2013) v.  Colombia (13 January 2013) v.  Paraguay (16 January 2013) v.  Paraguay (20 January 2013) v.  Ecuador (23 January 2013) v.  Uruguay (27 January 2013) v.  Colombia (30 January 2013) v.  Peru (3 February 2013)

Updated to 29 January 2013

No.	Pos.	Player
			Liga	Cup	Liga	Cup	Liga	Cup	Liga	Cup
1	GK	Andrés Palop			1
2	DF	Federico Fazio	3	1	2	1			2
3	DF	Fernando Navarro			5
4	DF	Emir Spahić	1		8	1
5	DF	Cala		1	2	1
6	MF	José Campaña			2
7	MF	Jesús Navas			2	1
8	MF	Gary Medel	3	1	6		1		1
9	FW	Álvaro Negredo	9	5	1
10	MF	Diego Perotti		1	1
11	MF	Ivan Rakitić	3	2	7		1
12	MF	Hedwiges Maduro			2	1
13	GK	Diego López (Out)							1
14	FW	Manu		2	1	1
15	MF	Piotr Trochowski (LTI)	2
16	MF	Antonio Luna (Out)		1	1				1
19	MF	José Antonio Reyes	3		2		1
20	FW	Baba Diawara		1
21	DF	Cicinho	1		4	1
22	MF	Geoffrey Kondogbia	1		1
23	DF	Coke			2		1
24	DF	Alberto Botía		1	7	1