Defending champion Esther Vergeer defeated Korie Homan in the final, 6–2, 6–2 to win the women's singles wheelchair tennis title at the 2008 French Open.

1. Esther Vergeer (champion)
2. Korie Homan (final)

	Quarterfinals							Semifinals							Final
	1	Esther Vergeer	6	6
		Jiske Griffioen	2	1
								1	Esther Vergeer	6	6
									Aniek Van Koot	1	1
		Aniek Van Koot	6	6
		Lucy Shuker	3	3
															1	Esther Vergeer	6	6
															2	Korie Homan	2	2
		Sharon Walraven	7	4	3
		Florence Gravellier	5	6	6
									Florence Gravellier	4	4
								2	Korie Homan	6	6
	WC	Marianna Lauro	1	3
	2	Korie Homan	6	6

• Draw