The 2006 Ordina Open women's singles title was won by Dutch player Michaëlla Krajicek. It was the 17th edition of the Ordina Open tennis tournament, played on outdoor grass courts in Rosmalen, 's-Hertogenbosch Netherlands. The tournament was held from 18 to 24 June 2006.

Defending champion Klára Koukalová lost in second round to unseeded Michaëlla Krajicek, who went on to win the title by defeating Dinara Safina 6–3, 6–4 in the final.

The first two seeds received a bye into the second round.

	Semifinals							Final
	1	Elena Dementieva	6	65	4
		Michaëlla Krajicek	1	77	6
									Michaëlla Krajicek	6	6
								2	Dinara Safina	3	4
		Eleni Daniilidou	3	6	4
	2	Dinara Safina	6	3	6

	First round							Second round							Quarterfinals							Semifinals
								1	E Dementieva	6	4	6
		J Schruff	2	3					E Vesnina	1	6	4
		E Vesnina	6	6											1	E Dementieva	78	6
		S Mirza	67	6	4										5	A Ivanovic	66	4
		I Benešová	79	2	6				I Benešová	3	5
	WC	A Molik	1	6	2			5	A Ivanovic	6	7
	5	A Ivanovic	6	3	6																	1	E Dementieva	6	65	4
	3	F Pennetta	5	3																			M Krajicek	1	77	6
		M Krajicek	7	6					M Krajicek	63	6	6
		K Koukalová	6	6					K Koukalová	77	4	3
	Q	V Ruano Pascual	4	3												M Krajicek	6
	Q	A Bondarenko	1												8	J Janković	6r
		N Li	1r					Q	A Bondarenko	4	6	65
	WC	M Boonstra	3	0				8	J Janković	6	1	77
	8	J Janković	6	6

	First round							Second round							Quarterfinals							Semifinals
	7	G Dulko	6	77
	Q	M Díaz Oliva	1	63				7	G Dulko	3	3
		J Zheng	4	1					E Daniilidou	6	6
		E Daniilidou	6	6												E Daniilidou	6	0
		E Takao	3	3											Q	P Suárez	2	0r
		J Kostanić	6	6					J Kostanić	2	0
	Q	P Suárez	6	6				Q	P Suárez	6	6
	4	M Kirilenko	4	3																			E Daniilidou	3	6	4
	6	A Medina Garrigues	6	3	1																	2	D Safina	6	3	6
		M Domachowska	3	6	6				M Domachowska	64	77	3
		L Granville	5	3				WC	B Schultz-McCarthy	77	63	6
	WC	B Schultz-McCarthy	7	6											WC	B Schultz-McCarthy	3	4
	LL	M Ani	5	6	0										2	D Safina	6	6
		ME Camerin	7	0	6				ME Camerin	6	2	1
								2	D Safina	4	6	6

• Main and Qualifying draw