2005–06 Eerste Klasse was a Dutch association football season of the Eerste Klasse.
Saturday champions were:
- A: SV Huizen
- B: TOGR
- C: SSV '65
- D: VV Nunspeet
- E: Oranje Nassau Groningen
Sunday champions were:
- A: HVV Hollandia
- B: VUC Den Haag
- C: Blauw Geel '38
- D: RKSV Groene Ster
- E: SC Enschede
- F: Meppeler Sport Club
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