Mark Philippoussis was the defending champion but lost in the second round to Juan Balcells.

Greg Rusedski won in the final 6–3, 6–4 against Andre Agassi.

A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.

	First round							Second round							Quarterfinals							Semifinals							Final
	WC/1	A Agassi	7	3	6
		H-T Lee	5	6	3			WC/1	A Agassi	6	6
		M Kratochvil	6	6					M Kratochvil	4	2
		D Sanguinetti	2	0											WC/1	A Agassi	6	6
		J Gimelstob	1	65												S Sargsian	1	3
		S Sargsian	6	77					S Sargsian	6	65	77
		W Arthurs	6	6					W Arthurs	4	77	62
	5	S Schalken	4	4																		WC/1	A Agassi	6	6
	3	M Philippoussis	6	67	6																	6	J-M Gambill	4	4
		M Hantschk	3	79	3			3	M Philippoussis	4	77	63
	SE	J Acasuso	5	1					J Balcells	6	64	77
		J Balcells	7	6												J Balcells	2	0
	WC	A Roddick	6	6											6	J-M Gambill	6	6
		C Woodruff	4	4				WC	A Roddick	65	61
		A Sá	3	77	3			6	J-M Gambill	77	77
	6	J-M Gambill	6	60	6																								WC/1	Andre Agassi	3	4
	LL	C Mamiit	2	2																									8	Greg Rusedski	6	6
	WC	G Ivanišević	6	6				WC	G Ivanišević	3	4
		P Goldstein	3	64				Q	X Malisse	6	6
	Q	X Malisse	6	77											Q	X Malisse	5	6	5
		M Gustafsson	3	6	6										4	T Haas	7	3	1/r
		A Gaudenzi	6	3	2				M Gustafsson	6	3	4
		C Vinck	4	5				4	T Haas	4	6	6
	4	T Haas	6	7																		Q	X Malisse	4	2
	8	G Rusedski	6	77																		8	G Rusedski	6	6
		H Levy	1	64				8	G Rusedski	6	6
	Q	R Furlan	6	7				Q	R Furlan	3	2
	Q	T Zíb	2	5											8	G Rusedski	5	6	6
		A Stoliarov	6	6											2	L Hewitt	7	1	4
	Q	R Delgado	2	2					A Stoliarov	2	710	3
	SE	S Lareau	3	1				2	L Hewitt	6	68	6
	2	L Hewitt	6	6

• 2001 Sybase Open Draw
• 2001 Sybase Open Qualifying Draw