The 2000–01 EHF Champions League was the 41st edition of Europe's premier club handball tournament. FC Barcelona was the reigning champion. SDC San Antonio won the title beating FC Barcelona in the final.

Team #1	Agg.	Team #2	1st match	2nd match
ASKİ SK	58 – 41	Granitas Kaunas	29 – 18	29 – 23
HC Berchem	44 – 68	Hapoël Rishon LeZion	25 – 31	19 – 37
Wybrzeże Gdańsk	53 – 46	SKP Secovce	30 – 22	23 – 24
SKA Minsk	52 – 42	HV Fiqas Aalsmeer	28 – 20	24 – 22
Haukar Hafnarfjörður	53 – 48	HC Eynatten	22 – 18	31 – 30
SPE Strovolos Nicosie	50 – 51	Remus Bärnbach-Köflach	26 – 27	24 – 24
Steaua Bucarest	57 – 52	Panellínios Athènes	30 – 26	27 – 26
Izviđač Ljubuški	41 – 54	ZTR Zaporizhia	23 – 24	18 – 30

Team #1	Agg.	Team #2	1st match	2nd match
CSKA Moscou	39 – 54	Wybrzeże Gdańsk	23 – 28	16 – 26
SKA Minsk	48 – 53	Pallamano Trieste	28 – 26	20 – 27
Montpellier HB	45 – 41	ZTR Zaporizhia	24 – 18	21 – 23
RK Lovćen Cetinje	60 – 39	Remus Bärnbach-Köflach	30 – 16	30 – 23
Hapoël Rishon LeZion	42 – 50	Redbergslids IK	23 – 26	19 – 24
ABC Braga	55 – 50	Haukar Hafnarfjörður	25 – 22	30 – 28
Steaua Bucarest	47 – 63	HC Baník Karviná	29 – 34	18 – 29
ASKİ SK	56 – 60	TV Suhr	32 – 21	24 – 29

Team	Pld	W	D	L	GF	GA	GD	Pts
Celje	6	5	1	0	183	145	+38	11
Badel 1862 Zagreb	6	4	1	1	155	137	+18	9
ASKI Ankara	6	1	0	5	153	167	−14	2
Redbergslids IK	6	1	0	5	131	173	−42	2

Team	Pld	W	D	L	GF	GA	GD	Pts
FC Barcelona	6	4	2	0	155	133	+22	10
Montpellier HB	6	3	1	2	146	141	+5	7
Dunaferr SE	6	3	1	2	143	145	−2	7
Wybrzeże Gdańsk	6	0	0	6	124	149	−25	0

Team	Pld	W	D	L	GF	GA	GD	Pts
ABC Braga	6	4	0	2	151	153	−2	8
THW Kiel	6	3	1	2	164	147	+17	7
GOG Gudme	6	3	0	3	165	158	+7	6
Pallamano Trieste	6	1	1	4	159	181	−22	3

Team	Pld	W	D	L	GF	GA	GD	Pts
Lovćen Cetinje	6	4	1	1	160	150	+10	9
SDC San Antonio	6	4	0	2	170	155	+15	8
IL Runar Sandefjord	6	2	0	4	151	165	−14	4
Banik Karvina	6	1	1	4	170	181	−11	3

Team #1	Agg.	Team #2	1st match	2nd match
Montpellier HB	47 – 52	Celje	24 – 23	23 – 29
Badel 1862 Zagreb	40 – 55	FC Barcelona	17 – 29	23 – 26
SDC San Antonio	49 – 37	ABC Braga	25 – 16	24 – 21
THW Kiel	59 – 51	Lovćen Cetinje	35 – 22	24 – 29

Team #1	Agg.	Team #2	1st match	2nd match
THW Kiel	56 – 57	FC Barcelona	28 – 24	28 – 33
SDC San Antonio	62 – 57	Celje	30 – 28	32 – 29

Team #1	Agg.	Team #2	1st match	2nd match
FC Barcelona	49 – 52	SDC San Antonio	24 - 30	25 - 22

• EHF Champions League website