Andre Agassi defeated Ivan Lendl in the final, 3–6, 6–2, 6–0 to win the men's singles tennis title at the 1992 Canadian Open.

Andrei Chesnokov was the reigning champion, but did not participate this year.

	Semifinals							Final
	10	Wally Masur	1	2
	3	Ivan Lendl	6	6
								3	Ivan Lendl	6	2	0
								2	Andre Agassi	3	6	6
	6	MaliVai Washington	6	2	1
	2	Andre Agassi	2	6	6

	First round							Second round							Third round							Quarterfinals
								1	P Korda	6	6
	WC	S Lareau	0	2					R Weiss	4	4
		R Weiss	6	6											1	P Korda	6	6
		L Lavalle	7	6											15	R Reneberg	4	2
	Q	N Kroon	5	4					L Lavalle	2	3
		P McEnroe	62	4				15	R Reneberg	6	6
	15	R Reneberg	77	6																		1	P Korda	63	6	3
	10	W Masur	4	6	6																	10	W Masur	77	4	6
		K Braasch	6	3	4			10	W Masur	4	6	6
	Q	M Stadling	64	6	2			Q	B Pearce	6	4	1
	Q	B Pearce	77	2	6										10	W Masur	4	6	6
		P Kühnen	77	6												P Kühnen	6	3	2
		M Damm	64	3					P Kühnen	7	3	7
								7	D Rostagno	5	6	5

	First round							Second round							Third round							Quarterfinals
								3	I Lendl	6	6
		J Bates	1	4					T Martin	3	2
		T Martin	6	6											3	I Lendl	6	6
		S Youl	7	6												S Youl	1	4
		D Marcelino	5	1					S Youl	77	6
		F Montana	3	3				13	J Tarango	65	4
	13	J Tarango	6	6																		3	I Lendl	6	6
	12	B Shelton	64	5																		5	J McEnroe	2	4
		J Stark	77	7					J Stark	6	7
		T Witsken	4	6	6				T Witsken	4	5
		A Mronz	6	4	0											J Stark	0	2
		J Grabb	6	77											5	J McEnroe	6	6
		G Raoux	4	62					J Grabb	1	1
								5	J McEnroe	6	6

	First round							Second round							Third round							Quarterfinals
								6	M Washington	4	77	6
	Q	R Schmidt	3	4					G Connell	6	64	1
		G Connell	6	6											6	M Washington	6	711
		L Herrera	6	3	4											K Curren	4	69
		K Curren	2	6	6				K Curren	6	6
		G Bloom	6	6					G Bloom	4	3
	11	G Pozzi	1	3																		6	M Washington	77	6
	14	M Schapers	5	4																		4	A Krickstein	65	1
		S Stolle	7	6					S Stolle	66	3
		H Holm	6	6					H Holm	78	6
	Q	K Thorne	4	4												H Holm	4	64
		A Thoms	711	6											4	A Krickstein	6	77
		F Roese	69	1					A Thoms	4	3
								4	A Krickstein	6	6

	First round							Second round							Third round							Quarterfinals
								8	A Mansdorf	6	6
		G Muller	2	4					C Adams	3	4
		C Adams	6	6											8	A Mansdorf	6	7
		C Pridham	6	78												C Pridham	2	5
	WC	A Sznajder	1	66					C Pridham	63	77	6
		J Stoltenberg	6	6					J Stoltenberg	77	63	4
	9	D Wheaton	3	4																		8	A Mansdorf	2	4
	16	C van Rensburg	77	4	4																	2	A Agassi	6	6
	Q	S Bryan	63	6	6			Q	S Bryan	4	3
	WC	M Laurendeau	64	6	5			WC	G Rusedski	6	6
	WC	G Rusedski	7	3	7										WC	G Rusedski	4	1
	WC	D Nestor	6	6											2	A Agassi	6	6
	Q	C Caratti	4	4				WC	D Nestor	1	3
								2	A Agassi	6	6

• 1992 Canadian Open draw