RPG may refer to:

• Rocket-propelled grenade, a shoulder-launched anti-tank weapon
  • Ruchnoi Protivotankoviy Granatomyot (Russian: Ручной Противотанковый Гранатомёт), hand-held anti-tank grenade launcher:
    • RPG-1
    • RPG-2
    • RPG-7
    • RPG-16
    • RPG-18
    • RPG-22
    • RPG-26
    • RPG-27
    • RPG-28
    • RPG-29
    • RPG-30
    • RPG-32
  • Ruchnaya Protivotankovaya Granata, hand-held anti-tank grenade:
    • RPG-6
    • RPG-40
    • RPG-43
• Regulation prescription glasses, eyeglasses issued by the American military

• Role-playing game, in which players act out the roles of characters in a narrative game
• Role-playing video game, a type of video game
• RPG (film), a 2013 Portuguese science-fiction film
• "RPG", a song by Sekai no Owari
• "RPG", a song by Kehlani from her mixtape While We Wait

• RPG Group, Indian business group
  • R. P. Goenka, Indian industrialist, founder of the group
• RPG Life Sciences, Indian pharmaceutical company
• Rally of the Guinean People (Rassemblement du Peuple Guinéen), Guinean political party
• Ryanair Pilot Group, Ryanair pilots' trade union
• Recycled Paper Greetings, greeting card company based in Chicago, US

• IBM RPG, a computer programming language
• Retrograde pyelogram, a medical imaging procedure to visualize the urinary tract
• Ribosomal Protein Gene Database, see Eukaryotic small ribosomal subunit (40S)

• Rebounds per game, of basketball rebounds

• All pages with titles beginning with RPG
• All pages with titles containing RPG