Route 253 is a north–south highway on the south shore of the St. Lawrence River. Its northern terminus is in East Angus at Route 112 and its southern terminus is at the Vermont border, where it becomes Vermont Route 253.

• East Hereford
• Saint-Venant-de-Paquette
• Saint-Malo
• Saint-Isidore-de-Clifton
• Cookshire-Eaton
• Westbury
• East Angus

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  Route 253 southern end at the Canada-US border.
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  Junction of Routes 210 and 253 in Sawyerville.
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  Eaton-Sawyerville Road (Routes 210 and 253) near Eaton.
• 
  Route 253 near Cookshire.

• List of Quebec provincial highways

• Route 253 on Google Maps
• Provincial Route Map (Courtesy of the Quebec Ministry of Transportation) (in French)