Alex or Alexander Lewis may refer to:

• Alex Lewis (linebacker) (born 1981), American football player
• Alex Lewis (offensive lineman) (born 1992), American football player
• Alex Lewis (musician) (born 1978), American musician with Yellowcard
• Alexander Lewis (mayor) (1822–1908), American businessman and mayor of Detroit, Michigan
• Alexander Lewis (actor), Australian actor
• Alexander Cameron Lewis, Canadian politician