Nicole Melichar-Martinez and Daria Saville defeated Lucie Hradecká and Sania Mirza in the final, 5–7, 7–5, [10–6] to win the doubles tennis title at the 2022 Internationaux de Strasbourg.^[1]

Alexa Guarachi and Desirae Krawczyk were the defending champions^[2] but chose not to participate.

Elise Mertens was in contention for the world no. 1 doubles ranking, but she and partner Diane Parry lost in the semifinals to Melichar-Martinez and Saville.

	First round							Quarterfinals							Semifinals							Final
	1	L Hradecká S Mirza	3	6	[10]
		L Kichenok T Mihalíková	6	3	[8]			1	L Hradecká S Mirza	6	77
		N Kichenok R Olaru	6	7					N Kichenok R Olaru	3	64
	PR	B Schoofs R van der Hoek	2	5											1	L Hradecká S Mirza	6	6
	3	Y Xu Z Yang	3	6	[7]											K Christian L Marozava	3	3
		K Piter K Zimmermann	6	3	[10]				K Piter K Zimmermann	6	3	[8]
		K Christian L Marozava	6	6					K Christian L Marozava	2	6	[10]
		A Fomina-Klotz A Gabueva	0	1																		1	L Hradecká S Mirza	7	5	[6]
		J Lohoff R Voráčová	3	1																			N Melichar-Martinez D Saville	5	7	[10]
		N Melichar-Martinez D Saville	6	6					N Melichar-Martinez D Saville	w/o
		M Kostyuk E-G Ruse	6	7					M Kostyuk E-G Ruse
	4	L Chan S Stosur	2	5												N Melichar-Martinez D Saville	6	6
		E Lechemia S Murray Sharan	1	4												E Mertens D Parry	3	3
		E Mertens D Parry	6	6					E Mertens D Parry	77	6
		V Heisen S Santamaria	1	63				2	S Aoyama H-c Chan	65	1
	2	S Aoyama H-c Chan	6	77

• Main draw