In enzymology, a 2-furoate—CoA ligase (EC 6.2.1.31) is an enzyme that catalyzes the chemical reaction

ATP + 2-furoate + CoA AMP + diphosphate + 2-furoyl-CoA

The 3 substrates of this enzyme are ATP, 2-furoate, and CoA, whereas its 3 products are AMP, diphosphate, and 2-furoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 2-furoate:CoA ligase (AMP-forming). This enzyme is also called 2-furoyl coenzyme A synthetase.

• Koenig K, Andreesen JR (1989). "Molybdenum Involvement in Aerobic Degradation of 2-Furoic Acid by Pseudomonas putida Fu1". Appl. Environ. Microbiol. 55 (7): 1829–1834. PMC 202958. PMID 16347977.