The First Canadian Ministry was the first cabinet chaired by Prime Minister John A. Macdonald. It governed Canada from 1 July 1867 to 5 November 1873, including all of the 1st Canadian Parliament as well as the first eight months of the Second. The government was formed by the Liberal-Conservative Party in coalition with the old Conservative Party of Canada. Macdonald was also Prime Minister in the Third Canadian Ministry.

• Prime Minister
  • 1 July 1867 – 7 November 1873: John A. Macdonald
• Minister of Agriculture
  • 1 July 1867 – 16 November 1869: Jean-Charles Chapais
  • 16 November 1869 – 25 October 1871: Christopher Dunkin
  • 25 October 1871 – 7 November 1873: John Henry Pope
• Minister of Customs
  • 1 July 1867 – 22 February 1873: Samuel Leonard Tilley
  • 22 February 1873 – 7 November 1873: Charles Tupper
• Minister of Finance
  • 1 July 1867 – 18 November 1867: Alexander Tilloch Galt
  • 18 November 1867 – 9 October 1869: John Rose
  • 9 October 1869 – 22 February 1873: Francis Hincks
  • 22 February 1873 – 7 November 1873: Samuel Leonard Tilley
• Superintendent-General of Indian Affairs
  • 22 May 1868 – 8 December 1869: The Secretary of State of Canada (Ex officio)
    • 22 May 1868 – 8 December 1869: Hector-Louis Langevin
  • 8 December 1869 – 1 July 1873: The Secretary of State of the Provinces (Ex officio)
    • 8 December 1869 – 7 May 1873: Joseph Howe
    • 7 May 1873 – 14 June 1873: James Cox Aikins (Acting)
    • 14 June 1873 – 1 July 1873: Thomas Nicholson Gibbs
  • 1 July 1873 – 7 November 1873: The Minister of the Interior (Ex officio)
    • 1 July 1873 – 7 November 1873: Alexander Campbell
• Minister of Inland Revenue
  • 1 July 1867 – 15 July 1868: William Pearce Howland
  • 15 July 1868 – 15 November 1869: Alexander Campbell (Acting)
  • 16 November 1869 – 2 July 1872Ai: Alexander Morris
  • 2 July 1872 – 4 March 1873: Charles Tupper
  • 4 March 1873 – 1 July 1873: John O'Connor
  • 1 July 1873 – 7 November 1873: Thomas Nicholson Gibbs
• Minister of the Interior
  • Was the Secretary of State for the Provinces to 30 June 1873.
  • 1 July 1873 – 7 November 1873: Alexander Campbell
• Minister of Justice
  • 1 July 1867 – 7 November 1873: John A. Macdonald
• Attorney General of Canada
  • 1 July 1867 – 7 November 1873: The Minister of Justice (Ex officio)
    • 1 July 1867 – 7 November 1873: John A. Macdonald
• Leader of the Government in the Senate
  • 1 July 1867 – 5 November 1873: Alexander Campbell
• Minister of Marine and Fisheries
  • 1 July 1867 – 7 November 1873: Peter Mitchell
• Minister of Militia and Defence
  • 1 July 1867 – 21 May 1873: George-Étienne Cartier
  • 21 May 1873 – 30 June 1873: Hector-Louis Langevin (Acting)
  • 1 July 1873 – 7 November 1873: Hugh McDonald
• Postmaster General
  • 1 July 1867 – 1 July 1873: Alexander Campbell
  • 1 July 1873 – 7 November 1873: John O'Connor
• President of the Privy Council
  • 1 July 1867 – 30 December 1867: Adam Johnston Fergusson Blair
  • 30 December 1867 – 30 January 1869: John A. Macdonald (Acting)
  • 30 January 1869 – 16 November 1869: Joseph Howe
  • 16 November 1869 – 21 June 1870: Edward Kenny
  • 21 June 1870 – 2 July 1872: Charles Tupper
  • 2 July 1872 – 4 March 1873: John O'Connor
  • 4 March 1873 – 14 June 1873: John A. Macdonald (Acting)
  • 14 June 1873 – 1 July 1873: Hugh McDonald
  • 1 July 1873 – 7 November 1873: John A. Macdonald (Acting)
• Minister of Public Works
  • 1 July 1867 – 29 September 1869: William McDougall
  • 29 September 1869 – 8 December 1869: Hector-Louis Langevin (Acting)
  • 8 December 1869 – 7 November 1873: Hector-Louis Langevin
• Receiver General
  • 1 July 1867 – 4 July 1867: Vacant
  • 4 July 1867 – 16 November 1869: Edward Kenny
  • 16 November 1869 – 30 January 1873: Jean-Charles Chapais
  • 30 January 1873 – 7 November 1873: Théodore Robitaille
• Secretary of State of Canada
  • 1 July 1867 – 8 December 1869: Hector-Louis Langevin
  • 8 December 1869 – 7 November 1873: James Cox Aikins
• Registrar General of Canada
  • 1 July 1867 – 7 November 1873: The Secretary of State of Canada (Ex officio)
    • 1 July 1867 – 8 December 1869: Hector-Louis Langevin
    • 8 December 1869 – 7 November 1873: James Cox Aikins
• Secretary of State for the Provinces
  • 1 July 1867 – 1 May 1868: Adams George Archibald
  • 1 May 1868 – 16 November 1869: Vacant (Edmund Allen Meredith was acting)
  • 16 November 1869 – 7 May 1873: Joseph Howe
  • 7 May 1873 – 14 June 1873: James Cox Aikins (Acting)
  • 14 June 1873 – 1 July 1873: Thomas Nicholson Gibbs
  • Became Minister of the Interior from 1 July 1873.

• Government of Canada. "First Ministry". Guide to Canadian Ministries since Confederation. Privy Council Office. Archived from the original on 17 November 2015. Retrieved 1 July 2010.