The third Inter-Cities Fairs Cup was the first to be played over a single season, namely the 1960–61 season. Birmingham City once again reached the final, but lost again over two legs, this time to Roma. Once again, a number of countries sent a representative team for one of their main cities.

	First round						Quarter-finals						Semi-finals						Final
	Inter Milan	8	6	14
	Hannover 96	2	1	3
							Inter Milan	5	0	5
							Belgrade XI	0	1	1
	Leipzig XI	5	1	6 (0)
	Belgrade XI	2	4	6 (2)
													Inter Milan	1	1	2
													Birmingham City	2	2	4
	KB	8	3	11
	Basel XI	1	3	4
							KB	4	0	4
							Birmingham City	4	5	9
	Birmingham City	3	2	5
	Újpesti Dózsa	2	1	3
																			Birmingham City	2	0	2
																			Roma	2	2	4
	Zagreb XI	1	3	4
	Barcelona	1	4	5
							Barcelona	4	2	6
							Hibernian	4	3	7
	Hibernian	—	—	w
	Lausanne-Sport	—	—	o
													Hibernian	2	3	5 (0)
													Roma	2	3	5 (6)
	Lyon	1	2	3
	Cologne XI	3	1	4
							Cologne XI	0	2	2 (1)
							Roma	2	0	2 (4)
	U. Saint-Gilloise	0	1	1
	Roma	0	4	4

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Inter Milan	14–3	Hannover 96	8–2	6–1
Leipzig XI	6–61	Belgrade XI	5–2	1–4
KB	11–4	Basel XI	8–1	3–3
Birmingham City	5–3	Újpesti Dózsa	3–2	2–1
Zagreb XI	4–5	Barcelona	1–1	3–4
Hibernian	(w/o)	Lausanne-Sport	–	–
Lyon	3–4	Cologne XI	1–3	2–1
Union Saint-Gilloise	1–4	Roma	0–0	1–4

¹ Belgrade XI progressed to the quarter-finals after beating Leipzig XI 2–0 in a play-off match.

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Inter Milan won 14–3 on aggregate.

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Barcelona FC won 5–4 on aggregate.

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Cologne XI won 4–3 on aggregate.

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Belgrade XI 6-6 Leipzig XI on aggregate.

Belgrade XI won 2–0 in play-off.

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KB won 11–4 on aggregate.

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Birmingham City won 5–3 on aggregate.

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Roma won 4–1 on aggregate.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Inter Milan	5–1	Belgrade XI	5–0	0–1
KB	4–9	Birmingham City	4–4	0–5
Barcelona	6–7	Hibernian	4–4	2–3
Cologne XI	2–21	Roma	0–2	2–0

¹ Roma progressed to the semi-finals after beating Cologne XI 4–1 in a play-off match.

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Inter Milan won 5–1 on aggregate.

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Birmingham City won 9–4 on aggregate.

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Hibernian won 7–6 on aggregate.

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Roma 2–2 Cologne XI on aggregate.

Roma won 4–1 in play-off.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Inter Milan	2–4	Birmingham City	1–2	1–2
Hibernian	5–51	Roma	2–2	3–3

¹ Roma progressed to the final after beating Hibernian 6–0 in a play-off match.

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Birmingham City won 4–2 on aggregate.

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Roma 5–5 Hibernian on aggregate.

Roma won 6–0 in play-off.

Roma won 4–2 on aggregate.

• Zea, Antonio; Haisma, Marcel (2 October 2009). "European Champions' Cup and Fairs' Cup 1960-61 - Details: Fairs' Cup 1960–61". RSSSF. Retrieved 13 September 2023.

• Corriere dello Sport match chronicle