Seoane is a toponymic surname of Galician origin, meaning "Saint John". It may refer to:

• Consuelo Seoane (1876–1964), colonel in the US Army (third cavalry)
• Diego Seoane Pérez (born 1988), Spanish footballer
• Fernando Seoane (born 1983), Spanish professional footballer
• Gerardo Seoane (born 1978), Swiss footballer
• Luís Seoane (1910–1979), lithographer and artist
• Manny Seoane (born 1955), retired professional baseball player
• Manuel Seoane (1902–1975), Argentine football striker
• María Seoane (1948–2023), Argentine journalist, writer, and film director
• Mariana Seoane (born 1976), Mexican actress, model and singer