Ro 3-0419 is a highly toxic organophosphate acetylcholinesterase inhibitor. It is the neutral analog of Ro 3-0422. Although Ro 3-0419 is less potent than Ro 3-0422, it does not have a positively charged nitrogen atom, resulting in its ability to cross the blood brain barrier to inhibit cholinesterases in the brain. The intravenous LD50 of Ro 3-0419 is 1 mg/kg in mice.[1]

See also

References

  1. ^ HOBBIGER, F (June 1954). "The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base". British Journal of Pharmacology and Chemotherapy. 9 (2): 159–65. doi:10.1111/j.1476-5381.1954.tb00835.x. PMC 1509437. PMID 13172424.
Allikas: https://en.wikipedia.org/wiki/Ro_3-0419
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