Perlmutter is a German and Ashkenazi Jewish surname. It may refer to:
- Adele Perlmutter (1845–1941), Austrian photographer
- Alvin H. Perlmutter, television producer
- David Perlmutter (born 1954), American physician and author
- David M. Perlmutter (born 1938), American linguist
- Ed Perlmutter (born 1953), US Congressman from Colorado
- Inbal Perlmutter (1971–1997), Israeli musician
- Isaac Perlmutter (born 1942), American businessman and financier
- Jordon Perlmutter (1931–2011), American real estate developer
- Richard Perlmutter, songwriter, singer and producer
- Roger Perlmutter, Merck research leader and scientist
- Saul Perlmutter (born 1959), Nobel laureate astrophysicist at Lawrence Berkeley National Laboratory
- Shira Perlmutter (born 1956), 14th and incumbent US Register of Copyrights
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