PLS or Pls may refer to:

• Pioneer Library System, Oklahoma, US
• Poculi Ludique Societas, Medieval & Renaissance Players of Toronto, Canada
• Profesjonalna Liga Siatkówki, Polish Volleyball League
• Premier League Soccer, an Indian football league
• Prometheus Light and Sound, US home PBX company, 1990s
• Pilbara Minerals Ltd, an Australian ASX-listed lithium mining company.

• Palomar–Leiden survey of minor planets
• Partial least squares regression, a statistical method
• Plasma spectrometer, an instrument aboard the Voyager 1 and 2 space probes
• Pregnant leach solution, a mining process

• PLS (complexity), a complexity class
• PLS (file format), multimedia playlist format
• Pronunciation Lexicon Specification, for interoperable pronunciation information
• Super PLS, a Samsung IPS panel technology
• IBM PL/S, a systems programming language
• Rand RL/S, Rand Corporation's version of IBM's PL/S

• Papillon–Lefèvre syndrome, a disease affecting the teeth and skin
• Plastin (PLS)
• Primary lateral sclerosis, a disease characterized by weakness
• Proteus-like syndrome, similar to Proteus syndrome
• Polish Lowland Sheepdog

• Palletized load system, U.S. Army logistics system
• Providenciales International Airport, Turks and Caicos Islands, IATA code
• Pleasington railway station, England, station code

• Texting shorthand for "please"
• Profit and loss sharing, a concept in Islamic finance similar to equity financing
• Public Land Strip, former name for the Oklahoma Panhandle

• All pages with titles beginning with PLS
• All pages with titles beginning with Pls
• All pages with titles containing pls
• Plis (disambiguation)
• Please (disambiguation)
• PLSS (disambiguation)
• PL (disambiguation), for the singular of PLs