Isser or Issur is a given name and surname. Notable people with this name include:
Given name
- Isser Be'eri (1901–1958), Israeli director of military intelligence
- Issur Demsky or Kirk Douglas (1916–2020), American actor
- Isser Harel (1912–2003), Israeli spymaster
- Isser Zalman Meltzer (1870–1953), Lithuanian Orthodox rabbi and scholar
- Isser Yehuda Unterman (1886–1976), Ashkenazi Chief Rabbi of Israel
- Isser Woloch (born 1937), historian of the French Revolution
Surname
- Aharon Isser (1958–1995), Israeli aeronautical engineer
- Franz Isser (born 1932), Austrian bobsledder
- Fritz Isser, Austrian bobsledder
- Heinrich Isser (1928–2004), Austrian bobsledder
- Josef Isser, Austrian luger
- Maria Isser (1929–2011), Austrian luger
- Paul Isser, Austrian luger
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