Iacopo is a given name, form of Jacopo, an Italian variation of Giacomo. May also refer to:

• Iacopo II Appiani (1400–1441), the lord of Piombino from 1405 until 1441
• Iacopo III Appiani (1422–1474), Prince of Piombino of the Appiani dynasty in the Renaissance
• Iacopo IV Appiani (1459–1510), Italian condottiero and lord of Piombino of the Appiani dynasty in the Renaissance
• Iacopo V Appiani (1480–1545), the lord of Piombino of the Appiani dynasty from 1511 until his death
• Iacopo Balestri (born 1975), Italian footballer
• Iacopo Jacomelli, Italian singer of 1940s
• Iacopo La Rocca (born 1984), Italian football defender
• Iacopo Rusticucci, 13th century Florentine politician
• Vitaliano di Iacopo Vitaliani, Paduan nobleman who lived in the late 13th century around the time of Giotto and Dante