Cod-THC (Codeine Δ9-tetrahydrocannabinol carbonate) is a synthetic codrug formed by linking tetrahydrocannabinol with codeine via a carbonate bridge. It is well absorbed orally and shows superior analgesic effects in animal studies compared to a simple mixture of the two drugs.[1][2][3]

See also

References

  1. ^ Banerjee A, Hayward JJ, Trant JF (May 2023). ""Breaking bud": the effect of direct chemical modifications of phytocannabinoids on their bioavailability, physiological effects, and therapeutic potential". Organic & Biomolecular Chemistry. 21 (18): 3715–3732. doi:10.1039/d3ob00068k. PMID 36825573. S2CID 256792029.
  2. ^ US 2008/0176885, Holtman JR, Crooks PA, Dhooper HK, "Novel synergistic opioid-cannabinoid codrug for pain management.", published 24 July 2008, assigned to University of Kentucky and Insys Therapeutics Inc. 
  3. ^ Crooks PA, Dhooper HK, Chakraborty U (2011). "Improving the Use of Drug Combination through the Codrug Approach". In Rautio J (ed.). Prodrugs and Targeted Delivery: Towards Better ADME Properties. Wiley. pp. 345–383 (374–376). ISBN 978-3-527-63318-0.
Allikas: https://en.wikipedia.org/wiki/Cod-THC
No tags for this post.